I hope so!
I think Kate will probably get pregnant again, and then we'll have a whole new set of milestones to match the present to the big three in the past. I also think we'll get more of Randall and Beth running the apartment, and their girls growing up, and more backstory on Jack and his brother. There will probably be some sort of big health scare with someone, way more "fill-in" on the year or two after Jack's death, and eventually Dr. K. passing on.
Tess's future could be a whole spin-off in itself, too.