My parents come by daily to feed/check on our pets, so they take in the mail and paper. If you don't have someone checking on your house suspend the mail and/or paper. Set automatic lights if you have them.
Make sure we have plenty of food/litter for the cats.
Do all laundry so the only loads we when we come home are from the trip.
Clean the house so it is clean when we come home.
Use up or give away parishables (foods).
Set/program the thermostat so it will not be running ice cold (or hot) while you are gone.
Close blinds.
Some people shut off gas lines.
If you do not have someone coming by daily, let a trusted neighbor know you will be out of town with an emergency number where you can be reached just in case.
Set alarm system if you have one.
LOCK YOUR DOORS (and windows) WHEN YOU LEAVE!!!
Don't post on FB/MS that you are leaving with dates or length of vacation...might as well send an invitation for burglary...or just some really jealous friends!