Santee is where we usually stop. We stay at the Hampton Inn - it's a nice new one and you can book online. It's right off 95, can't remember the exit number. It's also easy to get to if you drive down on 81 instead (this is what we did on our Dec. trip). Much nicer drive...unless it snows.
We've driven to Fl. (from No. NJ) several times a year for the last 10 years. Having done both, driving straight through and and stopping for the night, I'd definitely recommend stopping for the night. A few hours of sleep, a shower and breakfast get your vacation off to a better and safer start.