Been to both, on our on, not from a cruise. While we didn’t do anything in Genoa except drive around, it was a big city, I’m sure there are interesting things to see and do...but Portifino is magical. The village is lovely, lots of great shops. The port is beautiful with many little cafes and restaurants right on the water. I would go back to portifino in a heartbeat. Walk around, shop, have lunch, enjoy the ambiance.